I know a friend of mine, who have got her wife with PhD to work at a University as researcher. Having a PhD gives her a lot of advantage, she can apply for any of the schools for research or teaching roles. They may even sponsor her H1B visa, it will be cap exempt, if universities apply.
One of things she can do is to look at her PhD area and see, if the schools around your area has any demand for researchers. She can proactively reach out to schools in your area and share her credentials and PhD details and see, if any roles exist.