Can I submit DS 160 if my case status still in initial review ?

My employer received petition approved notice, but my case status still in initial review. Can I submit DS 160 ?

If I fill DS 160 and then if I got RFE status later then ?

I dont think you can submit DS 160 unless you get the confirmation/approval. Someone please correct me if i am wrong.

Can someone tell if one can submit DS-160 with I-797 but initial review status (some undelivered documents).